Cross-amyloid interaction of Aβ and IAPP at lipid membranes

Janine Seeliger; Florian Evers; Christoph Jeworrek; Shobhna Kapoor; Katrin Weise; Erika Andreetto; Metin Tolan; Aphrodite Kapurniotu; Roland Winter

doi:10.1002/anie.201105877

Cross-amyloid interaction of Aβ and IAPP at lipid membranes

Janine Seeliger, Florian Evers, Christoph Jeworrek, Shobhna Kapoor, Katrin Weise, Erika Andreetto, Metin Tolan, Aphrodite Kapurniotu, Roland Winter

Professur für Peptidbiochemie

Publikation: Beitrag in Fachzeitschrift › Artikel › Begutachtung

70 Zitate (Scopus)

Abstract

Membrane controlled protein assembly: A study of the amyloid interaction of the islet amyloid polypeptide (IAPP), β-amyloid (Aβ), and a mixture of both with an anionic model raft membrane showed the dominant effect of IAPP on the aggregation process and on the hydrogen-bonding pattern of the assemblies present in the mixture (see picture). The analysis of the interaction of Aβ with IAPP-GI-a non-amyloidogenic IAPP mimic-confirmed these findings.

Originalsprache	Englisch
Seiten (von - bis)	679-683
Seitenumfang	5
Fachzeitschrift	Angewandte Chemie International Edition in English
Jahrgang	51
Ausgabenummer	3
DOIs	https://doi.org/10.1002/anie.201105877
Publikationsstatus	Veröffentlicht - 16 Jan. 2012

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AU - Evers, Florian

AU - Jeworrek, Christoph

AU - Kapoor, Shobhna

AU - Weise, Katrin

AU - Andreetto, Erika

AU - Tolan, Metin

AU - Kapurniotu, Aphrodite

AU - Winter, Roland

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KW - IR spectroscopy

KW - X-ray diffraction

KW - fibril formation

KW - islet amyloid polypeptides

KW - β-amyloids

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Cross-amyloid interaction of Aβ and IAPP at lipid membranes

Abstract

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