Conservation of protein-protein interactions - Lessons from ascomycota

Philipp Pagel, Hans Werner Mewes, Dmitrij Frishman

Publikation: Beitrag in FachzeitschriftKurzer AbrissBegutachtung

34 Zitate (Scopus)

Abstract

Interacting proteins from Saccharomyces cerevisiae are evolutionarily conserved and their likelihood of having an ortholog in other ascomycota species correlates with the number of interaction partners. Moreover, interacting proteins show a clear preference to be conserved as a pair, indicating that nature maintains selection pressure on the interaction links between proteins. The conservation of interacting protein pairs between different organisms does not exhibit any bias with respect to protein functional roles.

OriginalspracheEnglisch
Seiten (von - bis)72-76
Seitenumfang5
FachzeitschriftTrends in Genetics
Jahrgang20
Ausgabenummer2
DOIs
PublikationsstatusVeröffentlicht - Feb. 2004

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