Concomitant Infection of S. mansoni and H. pylori Promotes Promiscuity of Antigen-Experienced Cells and Primes the Liver for a Lower Fibrotic Response

Sonakshi Bhattacharjee, Raquel Mejías-Luque, Eva Loffredo-Verde, Albulena Toska, Michael Flossdorf, Markus Gerhard, Clarissa Prazeres da Costa

Publikation: Beitrag in FachzeitschriftArtikelBegutachtung

11 Zitate (Scopus)

Abstract

Helicobacter pylori chronically colonizes the stomach and is strongly associated with gastric cancer. Its concomitant occurrence with helminths such as schistosomes has been linked to reduced cancer incidence, presumably due to suppression of H. pylori-associated pro-inflammatory responses. However, experimental evidence in support of such a causal link or the mutual interaction of both pathogens is lacking. We investigated the effects of co-infection during the different immune phases of S. mansoni infection. Surprisingly, co-infected mice had increased H. pylori gastric colonization during the interferon gamma (IFNγ) phase of schistosome infection but reduced infiltration of T cells in the stomach due to misdirection of antigen-experienced CXCR3+ T cells to the liver. Unexpectedly, H. pylori co-infection resulted in partial protection from schistosome-induced liver damage. Here, we demonstrate that an increase in fibrosis-protective IL-13Ra2 is associated with H. pylori infection. Thus, our study strongly points to an immunological interaction of anatomically isolated pathogens, eventually resulting in altered disease pathology. Co-infection is ubiquitous in human populations and is yet not the most widely studied experimental topic. Bhattacharjee et al. demonstrate that the immunological interaction of two prominent, anatomically isolated human pathogens, H. pylori and S. mansoni, eventually results in an unusual, mutually ameliorating effect on the detrimental course of both infections.

OriginalspracheEnglisch
Seiten (von - bis)231-244.e5
FachzeitschriftCell Reports
Jahrgang28
Ausgabenummer1
DOIs
PublikationsstatusVeröffentlicht - 2 Juli 2019

Fingerprint

Untersuchen Sie die Forschungsthemen von „Concomitant Infection of S. mansoni and H. pylori Promotes Promiscuity of Antigen-Experienced Cells and Primes the Liver for a Lower Fibrotic Response“. Zusammen bilden sie einen einzigartigen Fingerprint.

Dieses zitieren