TY - JOUR
T1 - Cognitive decline in Tg2576 mice shows sex-specific differences and correlates with cerebral amyloid-beta
AU - Schmid, Sebastian
AU - Rammes, Gerhard
AU - Blobner, Manfred
AU - Kellermann, Kristine
AU - Bratke, Sebastian
AU - Fendl, Diana
AU - Kaichuan, Zhu
AU - Schneider, Gerhard
AU - Jungwirth, Bettina
N1 - Publisher Copyright:
© 2018 Elsevier B.V.
PY - 2019/2/1
Y1 - 2019/2/1
N2 - Patients suffering from Alzheimer's disease show a sex-dependent decline of cognitive function. The aim of this investigation was to show these differences in an animal model for Alzheimer's disease and to determine whether this effect is correlated to amyloid-beta-induced pathophysiological changes. Therefore, we assessed cognitive performance with the modified hole-board test in female and male Tg2576 and wild type mice at the age of 6, 8, 10, 12, 14, and 16 months and correlated these findings to the total amount of soluble amyloid-beta and insoluble amyloid deposits in the brain. Tg2576 mice perform worse than wild types. Female Tg2576 mice develop an accentuated cognitive impairment (wrong choice total) beginning at the age of 12 months compared to their male littermates. Alterations in the mice's behaviour do not show interference with these deficits. Cognitive impairment is correlated to the amount of soluble amyloid-beta and insoluble amyloid deposits in the brain in a sex-dependent manner.
AB - Patients suffering from Alzheimer's disease show a sex-dependent decline of cognitive function. The aim of this investigation was to show these differences in an animal model for Alzheimer's disease and to determine whether this effect is correlated to amyloid-beta-induced pathophysiological changes. Therefore, we assessed cognitive performance with the modified hole-board test in female and male Tg2576 and wild type mice at the age of 6, 8, 10, 12, 14, and 16 months and correlated these findings to the total amount of soluble amyloid-beta and insoluble amyloid deposits in the brain. Tg2576 mice perform worse than wild types. Female Tg2576 mice develop an accentuated cognitive impairment (wrong choice total) beginning at the age of 12 months compared to their male littermates. Alterations in the mice's behaviour do not show interference with these deficits. Cognitive impairment is correlated to the amount of soluble amyloid-beta and insoluble amyloid deposits in the brain in a sex-dependent manner.
KW - Alzheimer's disease
KW - Amyloid-beta
KW - Cognitive impairment
KW - Modified hole-board test
KW - Sex differences
KW - Tg2576
UR - http://www.scopus.com/inward/record.url?scp=85057021755&partnerID=8YFLogxK
U2 - 10.1016/j.bbr.2018.11.022
DO - 10.1016/j.bbr.2018.11.022
M3 - Article
C2 - 30458163
AN - SCOPUS:85057021755
SN - 0166-4328
VL - 359
SP - 408
EP - 417
JO - Behavioural Brain Research
JF - Behavioural Brain Research
ER -