@inproceedings{1c93456dac47419e913be0d43c6e7caf,
title = "Characterization of Embryonic Cardiac Function Using Noninvasive Volumetric Optoacoustic Tomography",
abstract = "The heart is the first essential organ that develops during organogenesis. Fetal impaired heart function correlates to functional cardiac anomalies and heart defects in adulthood. Therefore, noninvasive assessment of dynamic functional cardiac events during pregnancy is essential for early diagnosis of cardiac diseases. However, visualization and analysis of the small yet fast-beating embryonic heart require a high-resolution imaging platform to provide reliable volumetric analyses. Optoacoustic (OA) imaging provides excellent optical contrast along with high spatial resolution and has demonstrated an exclusive potential for noninvasive deep-tissue visualization. In this study, we used volumetric OA imaging to visualize the embryonic heart at gestational day (GD) 16.5. The anatomical structure of the embryonic heart and cardiac vasculature was visualized in three orthogonal imaging planes allowing for further quantification and structural measurements. Twenty-five volumes per second temporal resolution of OA imaging enabled assessment of embryonic cardiac dynamics. Using the temporal profile of the time-lapse OA data at different locations of the embryonic heart, the average heart rate of embryos was calculated. This study demonstrated the capability of volumetric OA tomography for noninvasive visualization of the embryonic heart and assessment of cardio dynamics at nearly video rate.",
keywords = "Optoacoustic imaging, cardiac, embryo, functional imaging",
author = "Maryam Hatami and Ali {\"O}zbek and De{\'a}n-Ben, {Xos{\'e} Lu{\'i}s} and Jessica Gutierrez and Alexander Schill and Yogeshwari Ambekar and Daniel Razansky and Larin, {Kirill V.}",
note = "Publisher Copyright: {\textcopyright} 2023 SPIE.; Photons Plus Ultrasound: Imaging and Sensing 2023 ; Conference date: 29-01-2023 Through 01-02-2023",
year = "2023",
doi = "10.1117/12.2650483",
language = "English",
series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
publisher = "SPIE",
editor = "Oraevsky, {Alexander A.} and Wang, {Lihong V.}",
booktitle = "Photons Plus Ultrasound",
}