Challenges in the determination of total vitamin B12 by cyanidation conversion: insights from stable isotope dilution assays

Keyphrases

• Stable Isotope Dilution Assay 100%
• Vitamin B12 100%
• Cyanidation 100%
• Cyanocobalamin 66%
• Cobalamin 50%
• Method Validation 33%
• Inconsistency 16%
• Trace Amount 16%
• Monitoring Method 16%
• Further Development 16%
• Reliability Issues 16%
• Target Analyte 16%
• Reliable Monitoring 16%
• Liquid Chromatography-tandem Mass Spectrometry (LC-MS/MS) 16%
• Excellent Sensitivity 16%
• Assay Method 16%
• Meat Samples 16%
• Conversion Method 16%
• Vitamers 16%
• Analyte Stability 16%
• Analyte Concentration 16%
• Analytical Instrumentation 16%
• Immunoaffinity Purification 16%
• Recovery Accuracy 16%
• Day-to-day Variability 16%
• Inter-day Reliability 16%
• Instrument Stability 16%
• Sensitivity Recovery 16%
• Instrument Sensitivity 16%
• Incomplete Conversion 16%

Chemistry

• Cobalamin 100%
• Stable Isotope 100%
• Dilution 100%
• stability 100%
• Tandem Mass Spectrometry 33%
• Liquid Chromatography Mass Spectrometry 33%

Food Science

• Vitamin B12 100%
• Liquid Chromatography Mass Spectrometry 16%
• Tandem Mass Spectrometry 16%