Cellular solid-phase binding assay and mass spectrometry for screening of α4β7 integrin antagonists

Dirk Gottschling; Jürgen Boer; Anja Schuster; Bernhard Holzmann; Horst Kessler

doi:10.1016/S0960-894X(01)00611-4

Cellular solid-phase binding assay and mass spectrometry for screening of α4β7 integrin antagonists

Dirk Gottschling
, Jürgen Boer
, Anja Schuster
, Bernhard Holzmann
, Horst Kessler

Technische Universität München

Publikation: Beitrag in Fachzeitschrift › Artikel › Begutachtung

4 Zitate (Scopus)

Abstract

A qualitative cellular solid-phase binding assay for screening α4β7 integrin antagonists attached via photolinker to TentaGel® Macrobeads has been developed. An activation of the integrins with Mn²⁺ was necessary to achieve binding to the bead bound antagonists. The identification of the resin bound compounds was done by mass spectrometry.

Originalsprache	Englisch
Seiten (von - bis)	2997-3000
Seitenumfang	4
Fachzeitschrift	Bioorganic and Medicinal Chemistry Letters
Jahrgang	11
Ausgabenummer	23
DOIs	https://doi.org/10.1016/S0960-894X(01)00611-4
Publikationsstatus	Veröffentlicht - 3 Dez. 2001

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SDG 3 – Gute Gesundheit und Wohlergehen

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10.1016/S0960-894X(01)00611-4

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abstract = "A qualitative cellular solid-phase binding assay for screening α4β7 integrin antagonists attached via photolinker to TentaGel{\textregistered} Macrobeads has been developed. An activation of the integrins with Mn2+ was necessary to achieve binding to the bead bound antagonists. The identification of the resin bound compounds was done by mass spectrometry.",

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AU - Gottschling, Dirk

AU - Boer, Jürgen

AU - Schuster, Anja

AU - Holzmann, Bernhard

AU - Kessler, Horst

PY - 2001/12/3

Y1 - 2001/12/3

N2 - A qualitative cellular solid-phase binding assay for screening α4β7 integrin antagonists attached via photolinker to TentaGel® Macrobeads has been developed. An activation of the integrins with Mn2+ was necessary to achieve binding to the bead bound antagonists. The identification of the resin bound compounds was done by mass spectrometry.

AB - A qualitative cellular solid-phase binding assay for screening α4β7 integrin antagonists attached via photolinker to TentaGel® Macrobeads has been developed. An activation of the integrins with Mn2+ was necessary to achieve binding to the bead bound antagonists. The identification of the resin bound compounds was done by mass spectrometry.

UR - https://www.scopus.com/pages/publications/0035803052

U2 - 10.1016/S0960-894X(01)00611-4

DO - 10.1016/S0960-894X(01)00611-4

M3 - Article

C2 - 11714596

AN - SCOPUS:0035803052

SN - 0960-894X

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SP - 2997

EP - 3000

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 23

ER -

Cellular solid-phase binding assay and mass spectrometry for screening of α4β7 integrin antagonists

Abstract

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