Abstract
The activation of strong sp2 C-F bonds in catalytic C-C cross-coupling reactions with aryl Grignard reagents under mild conditions is possible: A nickel complex bearing an N-heterocyclic carbene ligand was identified as the most active catalyst for this reaction [Eq. (1)]. With the selective activation of aromatic C-F bonds over C-H bonds present, cross-coupling chemistry employing aryl halides has finally overcome its most challenging hurdle with regard to catalyst activity.
Originalsprache | Englisch |
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Seiten (von - bis) | 3387-3389 |
Seitenumfang | 3 |
Fachzeitschrift | Angewandte Chemie International Edition in English |
Jahrgang | 40 |
Ausgabenummer | 18 |
DOIs | |
Publikationsstatus | Veröffentlicht - 17 Sept. 2001 |