Ca²⁺ binding induced sequential allosteric activation of sortase A: An example for iontriggered conformational selection

Keyphrases

• Ca2+ 100%
• Conformational Selection 100%
• Sortase A 100%
• Ca2+ Binding 100%
• Allosteric Activation 100%
• Activation Mechanism 66%
• Cation Binding 66%
• Binding Energy 33%
• Signal Transmission 33%
• Structural Change 33%
• Trigger Mechanism 33%
• Structural Rearrangement 33%
• Catalytic Activity 33%
• Molecular Dynamics Simulation 33%
• Order-disorder Transition 33%
• Conformational States 33%
• Allosteric Regulation 33%
• Sorting Signal 33%
• Ca2+-binding Site 33%
• Binding Features 33%
• Staphylococcus Aureus Sortase A 33%
• Intrinsically Disordered Enzyme 33%
• Feature Binding 33%
• Folding-unfolding 33%
• Enzyme-triggered 33%
• Hinge Motion 33%
• Intrinsically Disordered Region 33%

Biochemistry, Genetics and Molecular Biology

• Sortase A 100%
• Enzyme 75%
• Motion 25%
• Dynamics 25%
• Signal Transduction 25%
• Enzymatic Activity 25%
• Allosteric Regulation 25%
• Binding Site 25%
• Binding Energy 25%
• Staphylococcus Aureus 25%
• Computer Simulation 25%