TY - JOUR
T1 - Case Series
T2 - Acute Hemorrhagic Encephalomyelitis After SARS-CoV-2 Vaccination
AU - Ancau, Mihai
AU - Liesche-Starnecker, Friederike
AU - Niederschweiberer, Johanna
AU - Krieg, Sandro M.
AU - Zimmer, Claus
AU - Lingg, Charlotte
AU - Kumpfmüller, Daniela
AU - Ikenberg, Benno
AU - Ploner, Markus
AU - Hemmer, Bernhard
AU - Wunderlich, Silke
AU - Mühlau, Mark
AU - Knier, Benjamin
N1 - Publisher Copyright:
Copyright © 2022 Ancau, Liesche-Starnecker, Niederschweiberer, Krieg, Zimmer, Lingg, Kumpfmüller, Ikenberg, Ploner, Hemmer, Wunderlich, Mühlau and Knier.
PY - 2022/2/2
Y1 - 2022/2/2
N2 - We present three cases fulfilling diagnostic criteria of hemorrhagic variants of acute disseminated encephalomyelitis (acute hemorrhagic encephalomyelitis, AHEM) occurring within 9 days after the first shot of ChAdOx1 nCoV-19. AHEM was diagnosed using magnetic resonance imaging, cerebrospinal fluid analysis and brain biopsy in one case. The close temporal association with the vaccination, the immune-related nature of the disease as well as the lack of other canonical precipitating factors suggested that AHEM was a vaccine-related adverse effect. We believe that AHEM might reflect a novel COVID-19 vaccine-related adverse event for which physicians should be vigilant and sensitized.
AB - We present three cases fulfilling diagnostic criteria of hemorrhagic variants of acute disseminated encephalomyelitis (acute hemorrhagic encephalomyelitis, AHEM) occurring within 9 days after the first shot of ChAdOx1 nCoV-19. AHEM was diagnosed using magnetic resonance imaging, cerebrospinal fluid analysis and brain biopsy in one case. The close temporal association with the vaccination, the immune-related nature of the disease as well as the lack of other canonical precipitating factors suggested that AHEM was a vaccine-related adverse effect. We believe that AHEM might reflect a novel COVID-19 vaccine-related adverse event for which physicians should be vigilant and sensitized.
KW - COVID-19
KW - ChAdOx1 nCoV-19
KW - Weston-Hurst syndrome
KW - acute disseminated encephalomyelitis
KW - acute hemorrhagic encephalomyelitis
KW - acute hemorrhagic leukoencephalitis
KW - vaccination
UR - http://www.scopus.com/inward/record.url?scp=85124886724&partnerID=8YFLogxK
U2 - 10.3389/fneur.2021.820049
DO - 10.3389/fneur.2021.820049
M3 - Article
AN - SCOPUS:85124886724
SN - 1664-2295
VL - 12
JO - Frontiers in Neurology
JF - Frontiers in Neurology
M1 - 820049
ER -