Carbohydrate derivatives for use in drug design: Cyclic α(v)-selective RGD peptides

Elisabeth Lohof; Eckart Planker; Christian Mang; Fred Burkhart; Michael A. Dechantsreiter; Roland Haubner; Hans Jürgen Wester; Markus Schwaiger; Günther Hölzemann; Simon L. Goodman; Horst Kessler

doi:10.1002/1521-3773(20000804)39:15<2761::AID-ANIE2761>3.0.CO;2-9

Carbohydrate derivatives for use in drug design: Cyclic α(v)-selective RGD peptides

Elisabeth Lohof, Eckart Planker, Christian Mang, Fred Burkhart, Michael A. Dechantsreiter, Roland Haubner, Hans Jürgen Wester, Markus Schwaiger, Günther Hölzemann, Simon L. Goodman, Horst Kessler

Publikation: Beitrag in Fachzeitschrift › Artikel › Begutachtung

144 Zitate (Scopus)

Abstract

To improve pharmacokinetic and -dynamic properties of peptidic, bioactive compounds they can be derivatized with carbohydrate building blocks. By incorporation into the peptidic backbone (see for example 1) the conformation of the pharmacophoric moieties can be influenced, while derivatization of side chains (see for example 2) mainly modifies the pharmacokinetic behavior.

Originalsprache	Englisch
Seiten (von - bis)	2761-2764
Seitenumfang	4
Fachzeitschrift	Angewandte Chemie International Edition in English
Jahrgang	39
Ausgabenummer	15
DOIs	https://doi.org/10.1002/1521-3773(20000804)39:15<2761::AID-ANIE2761>3.0.CO;2-9
Publikationsstatus	Veröffentlicht - 4 Aug. 2000

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10.1002/1521-3773(20000804)39:15<2761::AID-ANIE2761>3.0.CO;2-9

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Lohof, E., Planker, E., Mang, C., Burkhart, F., Dechantsreiter, M. A., Haubner, R., Wester, H. J., Schwaiger, M., Hölzemann, G., Goodman, S. L., & Kessler, H. (2000). Carbohydrate derivatives for use in drug design: Cyclic α(v)-selective RGD peptides. Angewandte Chemie International Edition in English, 39(15), 2761-2764. https://doi.org/10.1002/1521-3773(20000804)39:15<2761::AID-ANIE2761>3.0.CO;2-9

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abstract = "To improve pharmacokinetic and -dynamic properties of peptidic, bioactive compounds they can be derivatized with carbohydrate building blocks. By incorporation into the peptidic backbone (see for example 1) the conformation of the pharmacophoric moieties can be influenced, while derivatization of side chains (see for example 2) mainly modifies the pharmacokinetic behavior.",

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Lohof, E, Planker, E, Mang, C, Burkhart, F, Dechantsreiter, MA, Haubner, R, Wester, HJ , Schwaiger, M, Hölzemann, G, Goodman, SL & Kessler, H 2000, 'Carbohydrate derivatives for use in drug design: Cyclic α(v)-selective RGD peptides', Angewandte Chemie International Edition in English, Jg. 39, Nr. 15, S. 2761-2764. https://doi.org/10.1002/1521-3773(20000804)39:15<2761::AID-ANIE2761>3.0.CO;2-9

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T2 - Cyclic α(v)-selective RGD peptides

AU - Lohof, Elisabeth

AU - Planker, Eckart

AU - Mang, Christian

AU - Burkhart, Fred

AU - Dechantsreiter, Michael A.

AU - Haubner, Roland

AU - Wester, Hans Jürgen

AU - Schwaiger, Markus

AU - Hölzemann, Günther

AU - Goodman, Simon L.

AU - Kessler, Horst

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N2 - To improve pharmacokinetic and -dynamic properties of peptidic, bioactive compounds they can be derivatized with carbohydrate building blocks. By incorporation into the peptidic backbone (see for example 1) the conformation of the pharmacophoric moieties can be influenced, while derivatization of side chains (see for example 2) mainly modifies the pharmacokinetic behavior.

AB - To improve pharmacokinetic and -dynamic properties of peptidic, bioactive compounds they can be derivatized with carbohydrate building blocks. By incorporation into the peptidic backbone (see for example 1) the conformation of the pharmacophoric moieties can be influenced, while derivatization of side chains (see for example 2) mainly modifies the pharmacokinetic behavior.

KW - Carbohydrates

KW - Drug design

KW - Integrins

KW - Peptidomimetics

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ER -

Carbohydrate derivatives for use in drug design: Cyclic α(v)-selective RGD peptides

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