TY - JOUR
T1 - Brain meets pancreas
T2 - Netrin, an axon guidance molecule, controls epithelial cell migration
AU - Hebrok, Matthias
AU - Reichardt, Louis F.
PY - 2004/4
Y1 - 2004/4
N2 - A recent publication shows that two integrins, α6β4 and α3β1, interact with netrin-1, a protein best known for its role in axon guidance. Consistent with a role in pancreatic development in vivo, netrin is expressed together with these integrins in fetal pancreatic epithelium. The paper presents strong evidence that pancreatic epithelial cells adhere, spread and migrate on netrin-coated substrata through α6β4. Data also indicate that α3β1 mediates HGF-stimulated cell migration on netrin-coated substrata. These results indicate that netrins might have much broader functions than previously suspected.
AB - A recent publication shows that two integrins, α6β4 and α3β1, interact with netrin-1, a protein best known for its role in axon guidance. Consistent with a role in pancreatic development in vivo, netrin is expressed together with these integrins in fetal pancreatic epithelium. The paper presents strong evidence that pancreatic epithelial cells adhere, spread and migrate on netrin-coated substrata through α6β4. Data also indicate that α3β1 mediates HGF-stimulated cell migration on netrin-coated substrata. These results indicate that netrins might have much broader functions than previously suspected.
UR - http://www.scopus.com/inward/record.url?scp=1842451700&partnerID=8YFLogxK
U2 - 10.1016/j.tcb.2004.02.005
DO - 10.1016/j.tcb.2004.02.005
M3 - Short survey
C2 - 15134068
AN - SCOPUS:1842451700
SN - 0962-8924
VL - 14
SP - 153
EP - 155
JO - Trends in Cell Biology
JF - Trends in Cell Biology
IS - 4
ER -