@article{4858921c06eb49858e99ae905fd23f1a,
title = "Blimp1 Prevents Methylation of Foxp3 and Loss of Regulatory T Cell Identity at Sites of Inflammation",
abstract = " An inflammatory environment threatens the stability of Foxp3 + Treg cells. Garg et al. show that by expressing the transcriptional regulator Blimp1, Treg cells resist the IL-6-driven loss of Foxp3 in inflamed tissues. Blimp1 prevents the methylation and reduced expression of Foxp3 through inhibition of the methyltransferase Dnmt3a.",
keywords = "Blimp1, CNS, CNS2, DNA methyltransferases, Foxp3, Interleukin-6, epigenetic regulation, inflammation, regulatory T cells",
author = "Garima Garg and Andreas Muschaweckh and Helena Moreno and Ajithkumar Vasanthakumar and Stefan Floess and Gildas Lepennetier and Rupert Oellinger and Yifan Zhan and Tommy Regen and Michael Hiltensperger and Christian Peter and Lilian Aly and Benjamin Knier and Palam, {Lakshmi Reddy} and Reuben Kapur and Kaplan, {Mark H.} and Ari Waisman and Roland Rad and Gunnar Schotta and Jochen Huehn and Axel Kallies and Thomas Korn",
note = "Publisher Copyright: {\textcopyright} 2019 The Author(s)",
year = "2019",
month = feb,
day = "12",
doi = "10.1016/j.celrep.2019.01.070",
language = "English",
volume = "26",
pages = "1854--1868.e5",
journal = "Cell Reports",
issn = "2211-1247",
publisher = "Cell Press",
number = "7",
}