@article{b65f34c212244c058c32625ba395d201,
title = "Biological and clinical insights from genetics of insomnia symptoms",
abstract = "Insomnia is a common disorder linked with adverse long-term medical and psychiatric outcomes. The underlying pathophysiological processes and causal relationships of insomnia with disease are poorly understood. Here we identified 57 loci for self-reported insomnia symptoms in the UK Biobank (n = 453,379) and confirmed their effects on self-reported insomnia symptoms in the HUNT Study (n = 14,923 cases and 47,610 controls), physician-diagnosed insomnia in the Partners Biobank (n = 2,217 cases and 14,240 controls), and accelerometer-derived measures of sleep efficiency and sleep duration in the UK Biobank (n = 83,726). Our results suggest enrichment of genes involved in ubiquitin-mediated proteolysis and of genes expressed in multiple brain regions, skeletal muscle, and adrenal glands. Evidence of shared genetic factors was found between frequent insomnia symptoms and restless legs syndrome, aging, and cardiometabolic, behavioral, psychiatric, and reproductive traits. Evidence was found for a possible causal link between insomnia symptoms and coronary artery disease, depressive symptoms, and subjective well-being.",
author = "{HUNT All In Sleep} and Lane, {Jacqueline M.} and Jones, {Samuel E.} and Dashti, {Hassan S.} and Wood, {Andrew R.} and Aragam, {Krishna G.} and {van Hees}, {Vincent T.} and Strand, {Linn B.} and Winsvold, {Bendik S.} and Heming Wang and Jack Bowden and Yanwei Song and Krunal Patel and Anderson, {Simon G.} and Beaumont, {Robin N.} and Bechtold, {David A.} and Cade, {Brian E.} and Mary Haas and Sekar Kathiresan and Little, {Max A.} and Luik, {Annemarie I.} and Loudon, {Andrew S.} and Shaun Purcell and Richmond, {Rebecca C.} and Scheer, {Frank A.J.L.} and Barbara Schormair and Jessica Tyrrell and Winkelman, {John W.} and Juliane Winkelmann and Martinsen, {Amy E.} and Skogholt, {Anne H.} and Ben Brumpton and Winsvold, {Bendik S.} and B{\o}rge Sivertsen and Willer, {Cristen J.} and Daniela Bragantini and H{\aa}vard Kallestad and Imre Janszky and Guzey, {Ismail C.} and Zwart, {John Anker} and Nielsen, {Jonas B.} and Nilsen, {Kristian B.} and Kristian Hveem and Lars Fritsche and Pedersen, {Linda M.} and Strand, {Linn B.} and Gabrielsen, {Maiken E.} and Johnsen, {Marianne B.} and Lie, {Marie U.} and Morten Engstr{\o}m and Trond Sand",
note = "Publisher Copyright: {\textcopyright} 2019, The Author(s), under exclusive licence to Springer Nature America, Inc.",
year = "2019",
month = mar,
day = "1",
doi = "10.1038/s41588-019-0361-7",
language = "English",
volume = "51",
pages = "387--393",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "Nature Research",
number = "3",
}