@article{eefb828adb314e35bd3c24293d9df638,
title = "Baricitinib Blocks Cytokine-Mediated Downregulation of PAD1 in Human Keratinocytes: A Possible Molecular Link to the Effects of JAK Inhibitors in Atopic Dermatitis",
author = "Avinash Padhi and Rekha, \{Rokeya Sultana\} and Lisa Benrejdal and Grundeken, \{Marijke Elise\} and Magda Lourda and Marcus Ehrstr{\"o}m and Kilian Eyerich and P{\'a}ez, \{Isabel Tapia\} and Johansson, \{Emma K.\} and Maria Bradley and Peter Bergman and Josefin Lysell",
note = "Funding Information: We express our gratitude to all the patients and healthy donors who took part in the study. We would like to thank Dr Michel Simon (Toulouse Institute for Infectious and Inflammatory Diseases, University of Toulouse, Toulouse, France) for providing antibodies against native and deiminated FLG. We thank Professor Liv Eidsmo (Karolinska Institutet, Sweden and Leo Foundation Skin Immunology Research Center, University of Copenhagen, Denmark) for her technical support. We are grateful to the research nurses Maria Lundqvist, Helena Griehsel, and Inger Ed{\'e}n at Department of Dermatology, Karolinska University Hospital, for clinical sample collection. This work was supported by Hudfonden, Psoriasisfonden, G{\"o}sta A Karlssons 60-{\aa}rs fond, Magnus Bergvalls stiftelse, and {\AA}ke Wibergs stiftelse. JL was supported by Region Stockholm (clinical postdoctoral appointment). The graphical abstracts were created with BioRender.com . Funding Information: We express our gratitude to all the patients and healthy donors who took part in the study. We would like to thank Dr Michel Simon (Toulouse Institute for Infectious and Inflammatory Diseases, University of Toulouse, Toulouse, France) for providing antibodies against native and deiminated FLG. We thank Professor Liv Eidsmo (Karolinska Institutet, Sweden and Leo Foundation Skin Immunology Research Center, University of Copenhagen, Denmark) for her technical support. We are grateful to the research nurses Maria Lundqvist, Helena Griehsel, and Inger Ed{\'e}n at Department of Dermatology, Karolinska University Hospital, for clinical sample collection. This work was supported by Hudfonden, Psoriasisfonden, G{\"o}sta A Karlssons 60-{\aa}rs fond, Magnus Bergvalls stiftelse, and {\AA}ke Wibergs stiftelse. JL was supported by Region Stockholm (clinical postdoctoral appointment). The graphical abstracts were created with BioRender.com. Conceptualization: AP, PB, JL; Formal Analysis: AP, PB, JL; Funding Acquisition: JL, PB; Investigation: AP, RSR, LB, MEaG, ML; Methodology: AP, ITP; Resources: ME, ITP, KE, EKJ, MB, PB, JL; Supervision: PB, JL; Visualization: AP, ML; Writing - Original Draft Preparation: AP, PB, JL; Writing - Review and Editing: AP, ML, ITP, EKJ, MB, PB, JL",
year = "2023",
month = jul,
doi = "10.1016/j.jid.2022.12.012",
language = "English",
volume = "143",
pages = "1306--1309.e4",
journal = "Journal of Investigative Dermatology",
issn = "0022-202X",
publisher = "Elsevier B.V.",
number = "7",
}