Autoantibodies to zinc transporter 8 and SLC30A8 genotype stratify type 1 diabetes risk

P. Achenbach; V. Lampasona; U. Landherr; K. Koczwara; S. Krause; H. Grallert; C. Winkler; M. Pflüger; T. Illig; E. Bonifacio; A. G. Ziegler

doi:10.1007/s00125-009-1438-0

Autoantibodies to zinc transporter 8 and SLC30A8 genotype stratify type 1 diabetes risk

P. Achenbach
, V. Lampasona
, U. Landherr
, K. Koczwara
, S. Krause
, H. Grallert
, C. Winkler
, M. Pflüger
, T. Illig
, E. Bonifacio
, A. G. Ziegler

Klinik und Poliklinik für Kinder- und Jugendmedizin

Publikation: Beitrag in Fachzeitschrift › Artikel › Begutachtung

176 Zitate (Scopus)

Abstract

Aims/hypothesis: Our aim was to determine the relationships between autoantibodies to zinc transporter 8 (ZnT8), genotypes of the ZnT8-encoding gene SLC30A8 and type 1 diabetes risk. Methods: ZnT8 autoantibodies (ZnT8A) were measured in sera of 1,633 children with a first-degree family history of type 1 diabetes and who were prospectively followed from birth. Antibodies were measured by Protein A-based radiobinding assays and COOH-terminal (R325, W325 or Q325 variants) or NH₂-terminal constructs of human ZnT8. SLC30A8 genotyping at single-nucleotide polymorphism (SNP) rs13266634 was performed on 1,170 children. Results: Antibodies against COOH-terminal ZnT8 constructs (ZnT8A-COOH) develope.

Originalsprache	Englisch
Seiten (von - bis)	1881-1888
Seitenumfang	8
Fachzeitschrift	Diabetologia
Jahrgang	52
Ausgabenummer	9
DOIs	https://doi.org/10.1007/s00125-009-1438-0
Publikationsstatus	Veröffentlicht - Sept. 2009

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title = "Autoantibodies to zinc transporter 8 and SLC30A8 genotype stratify type 1 diabetes risk",

abstract = "Aims/hypothesis: Our aim was to determine the relationships between autoantibodies to zinc transporter 8 (ZnT8), genotypes of the ZnT8-encoding gene SLC30A8 and type 1 diabetes risk. Methods: ZnT8 autoantibodies (ZnT8A) were measured in sera of 1,633 children with a first-degree family history of type 1 diabetes and who were prospectively followed from birth. Antibodies were measured by Protein A-based radiobinding assays and COOH-terminal (R325, W325 or Q325 variants) or NH2-terminal constructs of human ZnT8. SLC30A8 genotyping at single-nucleotide polymorphism (SNP) rs13266634 was performed on 1,170 children. Results: Antibodies against COOH-terminal ZnT8 constructs (ZnT8A-COOH) develope.",

author = "P. Achenbach and V. Lampasona and U. Landherr and K. Koczwara and S. Krause and H. Grallert and C. Winkler and M. Pfl{\"u}ger and T. Illig and E. Bonifacio and Ziegler, \{A. G.\}",

note = "Funding Information: Acknowledgements This study received support from the Deutsche Forschungsgemeinschaft (ZI 310/12-6), the Juvenile Diabetes Re- search Foundation (1-2006-665), the European Union (EP7-HEALTH-2007, DIAPREPP N202013), the Federal Ministry of Education and Research of Germany (Kompetenznetz Diabetes mellitus/Competence Network for Diabetes mellitus, FKZ 01GI0805-07), the DFG-Center for Regenerative Therapies Dresden, Cluster of Excellence at the Dresden University of Technology, and the Helmholtz Center Munich. P. Achenbach was supported by the Juvenile Diabetes Research Foundation (11-2005-1117) and K. Koczwara by the NIH/DFG Research Career Transition Award Program (KO 3418/1-1). The authors thank U. Mollenhauer, A. J{\"a}ger and A. Knopff for technical support. This study forms part of the dissertation of U. Landherr.",

year = "2009",

month = sep,

doi = "10.1007/s00125-009-1438-0",

language = "English",

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pages = "1881--1888",

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issn = "0012-186X",

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T1 - Autoantibodies to zinc transporter 8 and SLC30A8 genotype stratify type 1 diabetes risk

AU - Achenbach, P.

AU - Lampasona, V.

AU - Landherr, U.

AU - Koczwara, K.

AU - Krause, S.

AU - Grallert, H.

AU - Winkler, C.

AU - Pflüger, M.

AU - Illig, T.

AU - Bonifacio, E.

AU - Ziegler, A. G.

N1 - Funding Information: Acknowledgements This study received support from the Deutsche Forschungsgemeinschaft (ZI 310/12-6), the Juvenile Diabetes Re- search Foundation (1-2006-665), the European Union (EP7-HEALTH-2007, DIAPREPP N202013), the Federal Ministry of Education and Research of Germany (Kompetenznetz Diabetes mellitus/Competence Network for Diabetes mellitus, FKZ 01GI0805-07), the DFG-Center for Regenerative Therapies Dresden, Cluster of Excellence at the Dresden University of Technology, and the Helmholtz Center Munich. P. Achenbach was supported by the Juvenile Diabetes Research Foundation (11-2005-1117) and K. Koczwara by the NIH/DFG Research Career Transition Award Program (KO 3418/1-1). The authors thank U. Mollenhauer, A. Jäger and A. Knopff for technical support. This study forms part of the dissertation of U. Landherr.

PY - 2009/9

Y1 - 2009/9

N2 - Aims/hypothesis: Our aim was to determine the relationships between autoantibodies to zinc transporter 8 (ZnT8), genotypes of the ZnT8-encoding gene SLC30A8 and type 1 diabetes risk. Methods: ZnT8 autoantibodies (ZnT8A) were measured in sera of 1,633 children with a first-degree family history of type 1 diabetes and who were prospectively followed from birth. Antibodies were measured by Protein A-based radiobinding assays and COOH-terminal (R325, W325 or Q325 variants) or NH2-terminal constructs of human ZnT8. SLC30A8 genotyping at single-nucleotide polymorphism (SNP) rs13266634 was performed on 1,170 children. Results: Antibodies against COOH-terminal ZnT8 constructs (ZnT8A-COOH) develope.

AB - Aims/hypothesis: Our aim was to determine the relationships between autoantibodies to zinc transporter 8 (ZnT8), genotypes of the ZnT8-encoding gene SLC30A8 and type 1 diabetes risk. Methods: ZnT8 autoantibodies (ZnT8A) were measured in sera of 1,633 children with a first-degree family history of type 1 diabetes and who were prospectively followed from birth. Antibodies were measured by Protein A-based radiobinding assays and COOH-terminal (R325, W325 or Q325 variants) or NH2-terminal constructs of human ZnT8. SLC30A8 genotyping at single-nucleotide polymorphism (SNP) rs13266634 was performed on 1,170 children. Results: Antibodies against COOH-terminal ZnT8 constructs (ZnT8A-COOH) develope.

UR - https://www.scopus.com/pages/publications/68449094246

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AN - SCOPUS:68449094246

SN - 0012-186X

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SP - 1881

EP - 1888

JO - Diabetologia

JF - Diabetologia

IS - 9

ER -

Autoantibodies to zinc transporter 8 and SLC30A8 genotype stratify type 1 diabetes risk

Abstract

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