@article{7428b2c309b045c4bf4306289ef0945d,
title = "Autoantibodies to zinc transporter 8 and SLC30A8 genotype stratify type 1 diabetes risk",
abstract = "Aims/hypothesis: Our aim was to determine the relationships between autoantibodies to zinc transporter 8 (ZnT8), genotypes of the ZnT8-encoding gene SLC30A8 and type 1 diabetes risk. Methods: ZnT8 autoantibodies (ZnT8A) were measured in sera of 1,633 children with a first-degree family history of type 1 diabetes and who were prospectively followed from birth. Antibodies were measured by Protein A-based radiobinding assays and COOH-terminal (R325, W325 or Q325 variants) or NH2-terminal constructs of human ZnT8. SLC30A8 genotyping at single-nucleotide polymorphism (SNP) rs13266634 was performed on 1,170 children. Results: Antibodies against COOH-terminal ZnT8 constructs (ZnT8A-COOH) develope.",
author = "P. Achenbach and V. Lampasona and U. Landherr and K. Koczwara and S. Krause and H. Grallert and C. Winkler and M. Pfl{\"u}ger and T. Illig and E. Bonifacio and Ziegler, {A. G.}",
note = "Funding Information: Acknowledgements This study received support from the Deutsche Forschungsgemeinschaft (ZI 310/12-6), the Juvenile Diabetes Re- search Foundation (1-2006-665), the European Union (EP7-HEALTH-2007, DIAPREPP N202013), the Federal Ministry of Education and Research of Germany (Kompetenznetz Diabetes mellitus/Competence Network for Diabetes mellitus, FKZ 01GI0805-07), the DFG-Center for Regenerative Therapies Dresden, Cluster of Excellence at the Dresden University of Technology, and the Helmholtz Center Munich. P. Achenbach was supported by the Juvenile Diabetes Research Foundation (11-2005-1117) and K. Koczwara by the NIH/DFG Research Career Transition Award Program (KO 3418/1-1). The authors thank U. Mollenhauer, A. J{\"a}ger and A. Knopff for technical support. This study forms part of the dissertation of U. Landherr.",
year = "2009",
month = sep,
doi = "10.1007/s00125-009-1438-0",
language = "English",
volume = "52",
pages = "1881--1888",
journal = "Diabetologia",
issn = "0012-186X",
publisher = "Springer Science and Business Media Deutschland GmbH",
number = "9",
}
