Augmenting anti-CD19 and anti-CD22 CAR T-cell function using PD-1-CD28 checkpoint fusion proteins

Franziska Blaeschke; Dana Stenger; Antonia Apfelbeck; Bruno L. Cadilha; Mohamed Reda Benmebarek; Jasmin Mahdawi; Eva Ortner; Mareike Lepenies; Nicola Habjan; Felicitas Rataj; Semjon Willier; Theresa Kaeuferle; Robbie G. Majzner; Dirk H. Busch; Sebastian Kobold; Tobias Feuchtinger

doi:10.1038/s41408-021-00499-z

Augmenting anti-CD19 and anti-CD22 CAR T-cell function using PD-1-CD28 checkpoint fusion proteins

Franziska Blaeschke, Dana Stenger, Antonia Apfelbeck, Bruno L. Cadilha, Mohamed Reda Benmebarek, Jasmin Mahdawi, Eva Ortner, Mareike Lepenies, Nicola Habjan, Felicitas Rataj, Semjon Willier, Theresa Kaeuferle, Robbie G. Majzner, Dirk H. Busch, Sebastian Kobold, Tobias Feuchtinger

Lehrstuhl für Medizinische Mikrobiologie, Immunologie und Hygiene

Publikation: Beitrag in Fachzeitschrift › Brief › Begutachtung

19 Zitate (Scopus)

Originalsprache	Englisch
Aufsatznummer	108
Fachzeitschrift	Blood Cancer Journal
Jahrgang	11
Ausgabenummer	6
DOIs	https://doi.org/10.1038/s41408-021-00499-z
Publikationsstatus	Veröffentlicht - Juni 2021

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10.1038/s41408-021-00499-z

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Blaeschke, F., Stenger, D., Apfelbeck, A., Cadilha, B. L., Benmebarek, M. R., Mahdawi, J., Ortner, E., Lepenies, M., Habjan, N., Rataj, F., Willier, S., Kaeuferle, T., Majzner, R. G., Busch, D. H., Kobold, S., & Feuchtinger, T. (2021). Augmenting anti-CD19 and anti-CD22 CAR T-cell function using PD-1-CD28 checkpoint fusion proteins. Blood Cancer Journal, 11(6), Artikel 108. https://doi.org/10.1038/s41408-021-00499-z

@article{d0fda83ee89446739840526ceb134ae2,

title = "Augmenting anti-CD19 and anti-CD22 CAR T-cell function using PD-1-CD28 checkpoint fusion proteins",

author = "Franziska Blaeschke and Dana Stenger and Antonia Apfelbeck and Cadilha, {Bruno L.} and Benmebarek, {Mohamed Reda} and Jasmin Mahdawi and Eva Ortner and Mareike Lepenies and Nicola Habjan and Felicitas Rataj and Semjon Willier and Theresa Kaeuferle and Majzner, {Robbie G.} and Busch, {Dirk H.} and Sebastian Kobold and Tobias Feuchtinger",

note = "Funding Information: We thank Tanja Wei{\ss}er and Nadine Stoll for excellent technical assistance. This work was supported by the Kinderkrebshilfe Ebersberg e.V., Elterninitiative Intern 3, Bettina Br{\"a}u Stiftung, Gertrud und Hugo Adler Stiftung, the Gesellschaft f{\"u}r Kinderkrebsforschung and the Renate & Roland Gruber Stiftung. S.W. was supported by the Else-Kr{\"o}ner-Fresenius Stiftung and D.S. was supported by the German Cancer Research Center/German Cancer Consortium (DKTK). J.M. was supported by the Deutsche Krebshilfe. E.O. was supported by the Kind-Philip-Stiftung. S.K. is supported by the Marie-Sklodowska-Curie Program Training Network for the Immunotherapy of Cancer funded by the H2020 Program of the European Union (Grant 641549), the Marie-Sklodowska-Curie Program Training Network for Optimizing Adoptive T-cell therapy (Grant 955575), both funded by the H2020 Program of the European Union, the Hector foundation, the International Doctoral Program i-Target: Immunotargeting of Cancer funded by the Elite Network of Bavaria; Melanoma Research Alliance Grants 409510; the German Cancer Aid; the Ernst-Jung-Stiftung (S.K.); LMU Munich{\textquoteright}s Institutional Strategy LMUexcellent within the framework of the German Excellence Initiative (S.E. and S.K.); the Bundesministerium f{\"u}r Bildung und Forschung; by the European Research Council Grant 756017, ARMOR-T (to S.K.), by the German Research Foundation (DFG), the Fritz-Bender-Foundation and the Jos{\'e}-Carreras Foundation. R.G.M. is the Taube Distinguished Scholar for Pediatric Immunotherapy at Stanford University School of Medicine.",

year = "2021",

month = jun,

doi = "10.1038/s41408-021-00499-z",

language = "English",

volume = "11",

journal = "Blood Cancer Journal",

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Blaeschke, F, Stenger, D, Apfelbeck, A, Cadilha, BL, Benmebarek, MR, Mahdawi, J, Ortner, E, Lepenies, M, Habjan, N, Rataj, F, Willier, S, Kaeuferle, T, Majzner, RG, Busch, DH, Kobold, S & Feuchtinger, T 2021, 'Augmenting anti-CD19 and anti-CD22 CAR T-cell function using PD-1-CD28 checkpoint fusion proteins', Blood Cancer Journal, Jg. 11, Nr. 6, 108. https://doi.org/10.1038/s41408-021-00499-z

TY - JOUR

T1 - Augmenting anti-CD19 and anti-CD22 CAR T-cell function using PD-1-CD28 checkpoint fusion proteins

AU - Blaeschke, Franziska

AU - Stenger, Dana

AU - Apfelbeck, Antonia

AU - Cadilha, Bruno L.

AU - Benmebarek, Mohamed Reda

AU - Mahdawi, Jasmin

AU - Ortner, Eva

AU - Lepenies, Mareike

AU - Habjan, Nicola

AU - Rataj, Felicitas

AU - Willier, Semjon

AU - Kaeuferle, Theresa

AU - Majzner, Robbie G.

AU - Busch, Dirk H.

AU - Kobold, Sebastian

AU - Feuchtinger, Tobias

N1 - Funding Information: We thank Tanja Weißer and Nadine Stoll for excellent technical assistance. This work was supported by the Kinderkrebshilfe Ebersberg e.V., Elterninitiative Intern 3, Bettina Bräu Stiftung, Gertrud und Hugo Adler Stiftung, the Gesellschaft für Kinderkrebsforschung and the Renate & Roland Gruber Stiftung. S.W. was supported by the Else-Kröner-Fresenius Stiftung and D.S. was supported by the German Cancer Research Center/German Cancer Consortium (DKTK). J.M. was supported by the Deutsche Krebshilfe. E.O. was supported by the Kind-Philip-Stiftung. S.K. is supported by the Marie-Sklodowska-Curie Program Training Network for the Immunotherapy of Cancer funded by the H2020 Program of the European Union (Grant 641549), the Marie-Sklodowska-Curie Program Training Network for Optimizing Adoptive T-cell therapy (Grant 955575), both funded by the H2020 Program of the European Union, the Hector foundation, the International Doctoral Program i-Target: Immunotargeting of Cancer funded by the Elite Network of Bavaria; Melanoma Research Alliance Grants 409510; the German Cancer Aid; the Ernst-Jung-Stiftung (S.K.); LMU Munich’s Institutional Strategy LMUexcellent within the framework of the German Excellence Initiative (S.E. and S.K.); the Bundesministerium für Bildung und Forschung; by the European Research Council Grant 756017, ARMOR-T (to S.K.), by the German Research Foundation (DFG), the Fritz-Bender-Foundation and the José-Carreras Foundation. R.G.M. is the Taube Distinguished Scholar for Pediatric Immunotherapy at Stanford University School of Medicine.

PY - 2021/6

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U2 - 10.1038/s41408-021-00499-z

DO - 10.1038/s41408-021-00499-z

M3 - Letter

C2 - 34088894

AN - SCOPUS:85107137844

SN - 2044-5385

VL - 11

JO - Blood Cancer Journal

JF - Blood Cancer Journal

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