Association of MRS-based vertebral bone marrow fat fraction with bone strength in a human in vitro model

Dimitrios C. Karampinos; Stefan Ruschke; Olga Gordijenko; Eduardo Grande Garcia; Hendrik Kooijman; Rainer Burgkart; Ernst J. Rummeny; Jan S. Bauer; Thomas Baum

doi:10.1155/2015/152349

Association of MRS-based vertebral bone marrow fat fraction with bone strength in a human in vitro model

Dimitrios C. Karampinos, Stefan Ruschke, Olga Gordijenko, Eduardo Grande Garcia, Hendrik Kooijman, Rainer Burgkart, Ernst J. Rummeny, Jan S. Bauer, Thomas Baum

Publikation: Beitrag in Fachzeitschrift › Artikel › Begutachtung

38 Zitate (Scopus)

Abstract

Bone marrow adiposity has recently gained attention due to its association with bone loss pathophysiology. In this study, ten vertebrae were harvested from fresh human cadavers. Trabecular BMD and microstructure parameters were extracted from MDCT. Bone marrow fat fractions were determined using single-voxel MRS. Failure load (FL) values were assessed by destructive biomechanical testing. Significant correlations (P < 0.05) were observed between MRS-based fat fraction and MDCT-based parameters (up to r =-0.72) and MRS-based fat fraction and FL (r =-0.77). These findings underline the importance of the bone marrow in the pathophysiology and imaging diagnostics of osteoporosis.

Originalsprache	Englisch
Aufsatznummer	152349
Fachzeitschrift	Journal of Osteoporosis
Jahrgang	2015
DOIs	https://doi.org/10.1155/2015/152349
Publikationsstatus	Veröffentlicht - 2015

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title = "Association of MRS-based vertebral bone marrow fat fraction with bone strength in a human in vitro model",

abstract = "Bone marrow adiposity has recently gained attention due to its association with bone loss pathophysiology. In this study, ten vertebrae were harvested from fresh human cadavers. Trabecular BMD and microstructure parameters were extracted from MDCT. Bone marrow fat fractions were determined using single-voxel MRS. Failure load (FL) values were assessed by destructive biomechanical testing. Significant correlations (P < 0.05) were observed between MRS-based fat fraction and MDCT-based parameters (up to r =-0.72) and MRS-based fat fraction and FL (r =-0.77). These findings underline the importance of the bone marrow in the pathophysiology and imaging diagnostics of osteoporosis.",

author = "Karampinos, {Dimitrios C.} and Stefan Ruschke and Olga Gordijenko and {Grande Garcia}, Eduardo and Hendrik Kooijman and Rainer Burgkart and Rummeny, {Ernst J.} and Bauer, {Jan S.} and Thomas Baum",

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year = "2015",

doi = "10.1155/2015/152349",

language = "English",

volume = "2015",

journal = "Journal of Osteoporosis",

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T1 - Association of MRS-based vertebral bone marrow fat fraction with bone strength in a human in vitro model

AU - Karampinos, Dimitrios C.

AU - Ruschke, Stefan

AU - Gordijenko, Olga

AU - Grande Garcia, Eduardo

AU - Kooijman, Hendrik

AU - Burgkart, Rainer

AU - Rummeny, Ernst J.

AU - Bauer, Jan S.

AU - Baum, Thomas

PY - 2015

Y1 - 2015

N2 - Bone marrow adiposity has recently gained attention due to its association with bone loss pathophysiology. In this study, ten vertebrae were harvested from fresh human cadavers. Trabecular BMD and microstructure parameters were extracted from MDCT. Bone marrow fat fractions were determined using single-voxel MRS. Failure load (FL) values were assessed by destructive biomechanical testing. Significant correlations (P < 0.05) were observed between MRS-based fat fraction and MDCT-based parameters (up to r =-0.72) and MRS-based fat fraction and FL (r =-0.77). These findings underline the importance of the bone marrow in the pathophysiology and imaging diagnostics of osteoporosis.

AB - Bone marrow adiposity has recently gained attention due to its association with bone loss pathophysiology. In this study, ten vertebrae were harvested from fresh human cadavers. Trabecular BMD and microstructure parameters were extracted from MDCT. Bone marrow fat fractions were determined using single-voxel MRS. Failure load (FL) values were assessed by destructive biomechanical testing. Significant correlations (P < 0.05) were observed between MRS-based fat fraction and MDCT-based parameters (up to r =-0.72) and MRS-based fat fraction and FL (r =-0.77). These findings underline the importance of the bone marrow in the pathophysiology and imaging diagnostics of osteoporosis.

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DO - 10.1155/2015/152349

M3 - Article

AN - SCOPUS:84929340391

SN - 2090-8059

VL - 2015

JO - Journal of Osteoporosis

JF - Journal of Osteoporosis

M1 - 152349

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Association of MRS-based vertebral bone marrow fat fraction with bone strength in a human in vitro model

Abstract

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