Applications of Coarse-Grained Models in Metabolic Engineering

Dieu Thi Doan, Manh Dat Hoang, Anna Lena Heins, Andreas Kremling

Publikation: Beitrag in FachzeitschriftArtikelBegutachtung

3 Zitate (Scopus)

Abstract

Mathematical modeling is a promising tool for better understanding of cellular processes. In recent years, the development of coarse-grained models has gained attraction since these simple models are able to capture and describe a broad range of growth conditions. Coarse-grained models often comprise only two cellular components, a low molecular component as representative for central metabolism and energy generation and a macromolecular component, representing the entire proteome. A framework is presented that presents a strict mass conservative model for bacterial growth during a biotechnological production process. After providing interesting properties for the steady-state solution, applications are presented 1) for a production process of an amino acid and 2) production of a metabolite from central metabolism.

OriginalspracheEnglisch
Aufsatznummer806213
FachzeitschriftFrontiers in Molecular Biosciences
Jahrgang9
DOIs
PublikationsstatusVeröffentlicht - 8 März 2022

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