Application of physiologically-based toxicokinetic modelling in oral-to-dermal extrapolation of threshold doses of cosmetic ingredients

Keyphrases

• Absorption Barriers 16%
• Absorption Phase 16%
• Area under the Curve 33%
• Biochemical Processes 16%
• Caffeine 16%
• Caucasian Population 16%
• Concentration Area 16%
• Cosmetic Products 100%
• Coumarin 16%
• Curve-based 16%
• Dermal Exposure 33%
• Experimental Values 16%
• Exposure Conditions 16%
• Exposure Scenario 16%
• Gastrointestinal Tract 16%
• Human Body 16%
• Hydroquinone 16%
• Internal Concentration 16%
• Liver Concentrations 16%
• Model Prediction 16%
• NOAEL 50%
• Oral Exposure 33%
• Peak Concentration 16%
• Penetration Parameter 16%
• Physiologically Based Toxicokinetic Model 100%
• Quantitative Structure-property Relationship 33%
• Rat Study 16%
• Result Prediction 16%
• Route-to-route Extrapolation 16%
• Simulation Performance 16%
• Skin Penetration 16%
• Subcompartment 16%
• Threshold Dose 100%

Pharmacology, Toxicology and Pharmaceutical Science

• Absorption Barrier 33%
• Cosmetics 100%
• Coumarin 33%
• Dermal Exposure 33%
• Hydroquinone 33%
• No-Observed-Adverse-Effect Level 100%
• Toxicokinetic Modeling 100%
• Toxicokinetics 100%