TY - JOUR
T1 - Antioxidant and vasorelaxant activities of the Turraeanthus africanus methanol extract
AU - Dongmo, Alain Bertand
AU - Dzikouk, Guillaume Dzissin
AU - Massoma, Dieudonné Lembé
AU - Nguelefak, Télesphore Benot
AU - Vardamides, Catherine Juliette
AU - Kamanyi, Albert
AU - Vierling, Wolfgang
N1 - Funding Information:
The authors wish to thank the University of Douala for financial assistance and the DAAD (German Academic Exchange Service) for the equipment grant allocated to one of the authors (A.B.D).
PY - 2009/12
Y1 - 2009/12
N2 - The present studies evaluate the antioxidant and vasorelaxant activities of the methanol stem bark extract of Turraeanthus africanus (Welw.) Pellegr. (Meliaceae). The antioxidant property investigated through the DPPH scavenging activity showed that the methanol extract from the stem bark of T. africanus was active with an inhibition rate of 72.47% at 500 μg/mL and IC50 of 29.2 μg/mL. This extract (0.1700 μg/mL) induced a concentration-dependent relaxation of guinea-pig aortic rings precontracted with noradrenaline or KCl, with a maximum relaxation reaching 87.55 and 97.42%, respectively, at a concentration of 700 μg/mL. The extract showed no significant effect on the electrically induced contraction of the guinea-pig papillary muscle. The results of this study indicate that the extract from the stem bark has interesting antioxidant and vasorelaxant properties and represents a potential source of medicine for the treatment of cardiovascular diseases.
AB - The present studies evaluate the antioxidant and vasorelaxant activities of the methanol stem bark extract of Turraeanthus africanus (Welw.) Pellegr. (Meliaceae). The antioxidant property investigated through the DPPH scavenging activity showed that the methanol extract from the stem bark of T. africanus was active with an inhibition rate of 72.47% at 500 μg/mL and IC50 of 29.2 μg/mL. This extract (0.1700 μg/mL) induced a concentration-dependent relaxation of guinea-pig aortic rings precontracted with noradrenaline or KCl, with a maximum relaxation reaching 87.55 and 97.42%, respectively, at a concentration of 700 μg/mL. The extract showed no significant effect on the electrically induced contraction of the guinea-pig papillary muscle. The results of this study indicate that the extract from the stem bark has interesting antioxidant and vasorelaxant properties and represents a potential source of medicine for the treatment of cardiovascular diseases.
KW - Antioxidant activity
KW - Turraeanthus africanus
KW - Vasorelaxant activity
UR - http://www.scopus.com/inward/record.url?scp=70450199368&partnerID=8YFLogxK
U2 - 10.3109/13880200903008674
DO - 10.3109/13880200903008674
M3 - Article
AN - SCOPUS:70450199368
SN - 1388-0209
VL - 47
SP - 1123
EP - 1129
JO - Pharmaceutical Biology
JF - Pharmaceutical Biology
IS - 12
ER -
