An Integrated Design, Material, and Fabrication Platform for Engineering Biomechanically and Biologically Functional Soft Tissues

Onur Bas; Davide D'Angella; Jeremy G. Baldwin; Nathan J. Castro; Felix M. Wunner; Navid T. Saidy; Stefan Kollmannsberger; Alessandro Reali; Ernst Rank; Elena M. De-Juan-Pardo; Dietmar W. Hutmacher

doi:10.1021/acsami.7b08617

An Integrated Design, Material, and Fabrication Platform for Engineering Biomechanically and Biologically Functional Soft Tissues

Onur Bas, Davide D'Angella, Jeremy G. Baldwin, Nathan J. Castro, Felix M. Wunner, Navid T. Saidy, Stefan Kollmannsberger, Alessandro Reali, Ernst Rank, Elena M. De-Juan-Pardo, Dietmar W. Hutmacher

Engineering and Design

Publikation: Beitrag in Fachzeitschrift › Artikel › Begutachtung

88 Zitate (Scopus)

Abstract

We present a design rationale for stretchable soft network composites for engineering tissues that predominantly function under high tensile loads. The convergence of 3D-printed fibers selected from a design library and biodegradable interpenetrating polymer networks (IPNs) result in biomimetic tissue engineered constructs (bTECs) with fully tunable properties that can match specific tissue requirements. We present our technology platform using an exemplary soft network composite model that is characterized to be flexible, yet ∼125 times stronger (E = 3.19 MPa) and ∼100 times tougher (W_Ext = ∼2000 kJ m^-3) than its hydrogel counterpart.

Originalsprache	Englisch
Seiten (von - bis)	29430-29437
Seitenumfang	8
Fachzeitschrift	ACS Applied Materials and Interfaces
Jahrgang	9
Ausgabenummer	35
DOIs	https://doi.org/10.1021/acsami.7b08617
Publikationsstatus	Veröffentlicht - 6 Sept. 2017

Zugriff auf Dokument

10.1021/acsami.7b08617

Andere Dateien und Links

Verknüpfung zur Publikation in Scopus

Dieses zitieren

Bas, O., D'Angella, D., Baldwin, J. G., Castro, N. J., Wunner, F. M., Saidy, N. T., Kollmannsberger, S., Reali, A., Rank, E., De-Juan-Pardo, E. M., & Hutmacher, D. W. (2017). An Integrated Design, Material, and Fabrication Platform for Engineering Biomechanically and Biologically Functional Soft Tissues. ACS Applied Materials and Interfaces, 9(35), 29430-29437. https://doi.org/10.1021/acsami.7b08617

@article{1d58b7dbbfc6428d997c0b87cb5e1d89,

title = "An Integrated Design, Material, and Fabrication Platform for Engineering Biomechanically and Biologically Functional Soft Tissues",

abstract = "We present a design rationale for stretchable soft network composites for engineering tissues that predominantly function under high tensile loads. The convergence of 3D-printed fibers selected from a design library and biodegradable interpenetrating polymer networks (IPNs) result in biomimetic tissue engineered constructs (bTECs) with fully tunable properties that can match specific tissue requirements. We present our technology platform using an exemplary soft network composite model that is characterized to be flexible, yet ∼125 times stronger (E = 3.19 MPa) and ∼100 times tougher (WExt = ∼2000 kJ m-3) than its hydrogel counterpart.",

keywords = "3D printing, biomimetic, fiber reinforcement, hydrogel, interpenetrating polymer network, melt electrospinning writing, soft network composite, tissue engineering",

author = "Onur Bas and Davide D'Angella and Baldwin, {Jeremy G.} and Castro, {Nathan J.} and Wunner, {Felix M.} and Saidy, {Navid T.} and Stefan Kollmannsberger and Alessandro Reali and Ernst Rank and De-Juan-Pardo, {Elena M.} and Hutmacher, {Dietmar W.}",

note = "Publisher Copyright: {\textcopyright} 2017 American Chemical Society.",

year = "2017",

month = sep,

day = "6",

doi = "10.1021/acsami.7b08617",

language = "English",

volume = "9",

pages = "29430--29437",

journal = "ACS Applied Materials and Interfaces",

issn = "1944-8244",

publisher = "American Chemical Society",

number = "35",

}

Bas, O, D'Angella, D, Baldwin, JG, Castro, NJ, Wunner, FM, Saidy, NT, Kollmannsberger, S, Reali, A, Rank, E, De-Juan-Pardo, EM & Hutmacher, DW 2017, 'An Integrated Design, Material, and Fabrication Platform for Engineering Biomechanically and Biologically Functional Soft Tissues', ACS Applied Materials and Interfaces, Jg. 9, Nr. 35, S. 29430-29437. https://doi.org/10.1021/acsami.7b08617

TY - JOUR

T1 - An Integrated Design, Material, and Fabrication Platform for Engineering Biomechanically and Biologically Functional Soft Tissues

AU - Bas, Onur

AU - D'Angella, Davide

AU - Baldwin, Jeremy G.

AU - Castro, Nathan J.

AU - Wunner, Felix M.

AU - Saidy, Navid T.

AU - Kollmannsberger, Stefan

AU - Reali, Alessandro

AU - Rank, Ernst

AU - De-Juan-Pardo, Elena M.

AU - Hutmacher, Dietmar W.

PY - 2017/9/6

Y1 - 2017/9/6

N2 - We present a design rationale for stretchable soft network composites for engineering tissues that predominantly function under high tensile loads. The convergence of 3D-printed fibers selected from a design library and biodegradable interpenetrating polymer networks (IPNs) result in biomimetic tissue engineered constructs (bTECs) with fully tunable properties that can match specific tissue requirements. We present our technology platform using an exemplary soft network composite model that is characterized to be flexible, yet ∼125 times stronger (E = 3.19 MPa) and ∼100 times tougher (WExt = ∼2000 kJ m-3) than its hydrogel counterpart.

AB - We present a design rationale for stretchable soft network composites for engineering tissues that predominantly function under high tensile loads. The convergence of 3D-printed fibers selected from a design library and biodegradable interpenetrating polymer networks (IPNs) result in biomimetic tissue engineered constructs (bTECs) with fully tunable properties that can match specific tissue requirements. We present our technology platform using an exemplary soft network composite model that is characterized to be flexible, yet ∼125 times stronger (E = 3.19 MPa) and ∼100 times tougher (WExt = ∼2000 kJ m-3) than its hydrogel counterpart.

KW - 3D printing

KW - biomimetic

KW - fiber reinforcement

KW - hydrogel

KW - interpenetrating polymer network

KW - melt electrospinning writing

KW - soft network composite

KW - tissue engineering

UR - http://www.scopus.com/inward/record.url?scp=85028937233&partnerID=8YFLogxK

U2 - 10.1021/acsami.7b08617

DO - 10.1021/acsami.7b08617

M3 - Article

C2 - 28816441

AN - SCOPUS:85028937233

SN - 1944-8244

VL - 9

SP - 29430

EP - 29437

JO - ACS Applied Materials and Interfaces

JF - ACS Applied Materials and Interfaces

IS - 35

ER -

An Integrated Design, Material, and Fabrication Platform for Engineering Biomechanically and Biologically Functional Soft Tissues

Abstract

Zugriff auf Dokument

Andere Dateien und Links

Fingerprint

Dieses zitieren