An Hsp70 peptide initiates NK cell killing of leukemic blasts after stem cell transplantation

Catharina Gross, Ernst Holler, Stefan Stangl, Anne Dickinson, A. Graham Pockley, Alexzander A. Asea, Nagaraja Mallappa, Gabriele Multhoff

Publikation: Beitrag in FachzeitschriftArtikelBegutachtung

16 Zitate (Scopus)

Abstract

In contrast to solid tumors, leukemic blasts frequently present both Hsp70 and HLA-E on their cell surface and thereby present activating and inhibitory signals to CD94+ NK cells. In the first 12 months after stem cell transplantation (SCT) CD94+ NK cells clearly dominate over CD3+/CD16-/56- T and CD3+/CD16+/56+ NK-like T cells. An incubation of post-SCT-derived peripheral blood lymphocytes with the Hsp70 peptide TKD and IL-15 enhances the cell surface density of CD56/CD94 and initiates the cytolytic activity of NK cells against Hsp70/HLA-E double-positive autologous and allogeneic leukemic blasts. Hsp70 was identified as the target structure for TKD-activated NK cells.

OriginalspracheEnglisch
Seiten (von - bis)527-534
Seitenumfang8
FachzeitschriftLeukemia Research
Jahrgang32
Ausgabenummer4
DOIs
PublikationsstatusVeröffentlicht - Apr. 2008

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