An enantioselective synthesis of the C₂₄-C₄₀ fragment of (−)-pulvomycin

The C₂₄-C₄₀ fragment of (−)-pulvomycin was prepared in enantiomerically pure form using a concise synthesis method (15 linear steps from d-fucose, 6.8% overall yield) featuring a diastereoselective addition to an aldehyde, a β-selective glycosylation and a Stille cross-coupling as the key steps.