Altered signalling from germline to intestine pushes daf-2;pept-1 Caenorhabditis elegans into extreme longevity

Keyphrases

• Caenorhabditis Elegans 100%
• Daf-2 100%
• Intestine 100%
• Germ Cells 100%
• Extreme Longevity 100%
• Altered Signaling 100%
• Expression Level 20%
• DAF-12 20%
• DAF-16 20%
• Reactive Oxygen Species 10%
• Metabolism 10%
• Interdependence 10%
• Gain-of-function mutation 10%
• Molecular Mechanism 10%
• Dipeptide 10%
• Signaling Pathway 10%
• Stress Resistance 10%
• Functional Level 10%
• Tripeptide 10%
• Glutathione 10%
• Signaling Cascades 10%
• Insulin-like 10%
• Transcript Level 10%
• Insulin Receptor 10%
• Microarray 10%
• Eukaryotes 10%
• Proper Function 10%
• Hormone Signaling 10%
• Central Regulator 10%
• Intestinal Peptides 10%
• Synthesis Rate 10%
• Endocrine Hormones 10%
• Peptide Transporter 1 (PepT1) 10%
• Transcriptomic Data 10%
• Downregulated Genes 10%

Biochemistry, Genetics and Molecular Biology

• Germline 100%
• Caenorhabditis Elegans 100%
• Daf-2 100%
• Germ Cell 100%
• Lifespan 30%
• Metabolic Pathway 10%
• Signal Transduction 10%
• Wild Type 10%
• Enzyme 10%
• Eukaryote 10%
• Loss of Function Mutation 10%
• Stress 10%
• Insulin Receptor 10%
• Dipeptide 10%
• Glutathione 10%
• Tripeptide 10%
• Transcriptome 10%