Activation of mGlu receptors induces LTD without affecting postsynaptic sensitivity of CA1 neurons in rat hippocampal slices

Gerhard Rammes, Mary Palmer, Matthias Eder, Hans Ulrich Dodt, Walter Zieglgänsberger, Graham L. Collingridge

Publikation: Beitrag in FachzeitschriftÜbersichtsartikelBegutachtung

45 Zitate (Scopus)

Abstract

Two forms of long-term depression (LTD) of excitatory synaptic transmission have been identified in the mammalian CNS, which are induced by the synaptic activation of N-methyl-D-aspartate (NMDA) and metabotropic glutamate (mGlu) receptors, respectively. The mGlu receptor-dependent form of LTD can be activated by application of 3,5-dihydroxyphenylglycine (DHPG), a group I selective mGlu receptor agonist. DHPG-induced LTD is increasingly being used to investigate the mechanisms of mGlu receptor-dependent LTD. However, recent experiments have argued for both a pre- and postsynaptic locus of expression of DHPG-induced LTD. In the present study we report that DHPG-induced LTD is not associated with changes in the sensitivity of CA1 neurons to bath applied AMPA. Furthermore, in contrast to homosynaptic LTD, DHPG-induced LTD is also not associated with changes in sensitivity to focally uncaged L-glutamate. These data do not support the notion that DHPG-induced LTD requires a modification of AMPA receptors, such as their internalisation, but are compatible with a presynaptic mechanism of expression.

OriginalspracheEnglisch
Seiten (von - bis)455-460
Seitenumfang6
FachzeitschriftJournal of Physiology
Jahrgang546
Ausgabenummer2
DOIs
PublikationsstatusVeröffentlicht - 15 Jan. 2003
Extern publiziertJa

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