A unified mechanism for proteolysis and autocatalytic activation in the 20S proteasome

Keyphrases

• Proteolysis 100%
• Threonine 100%
• 20S Proteasome 100%
• Autocatalytic Activation 100%
• Propeptide 66%
• Active Sites 66%
• X-ray Crystallography 33%
• Nucleophile 33%
• Hydroxyl Group 33%
• Nucleophilic Attack 33%
• Self-activation 33%
• Protease 33%
• Evolutionary Pressure 33%
• Biogenesis 33%
• Mutagenesis 33%
• Biochemical Assay 33%
• Catalytic Triad 33%
• Autolysis 33%
• Strict Conservation 33%
• Procollagen Type 1 N-terminal Propeptide (P1NP) 33%

Biochemistry, Genetics and Molecular Biology

• Proteasome 100%
• Proteolysis 100%
• Active Site 50%
• Threonine 50%
• N-Terminus 25%
• X-Ray Crystallography 25%
• Wild Type 25%
• Mutagenesis 25%
• Catalytic Triad 25%
• Nucleophilicity 25%
• Threonine Protease 25%
• Biogenesis 25%