TY - GEN
T1 - A Tractography Analysis for Electroconvulsive Therapy
AU - Riel, Stefanie
AU - Bashiri, Mohammad
AU - Hemmert, Werner
AU - Bai, Siwei
N1 - Publisher Copyright:
© 2018 IEEE.
PY - 2018/10/26
Y1 - 2018/10/26
N2 - Computational human head models have been used in electrophysiological studies, and they have been able to provide useful information that is unable or difficult to acquire from experimental or imaging studies. However, most of these models are purely volume conductor models that overlooked the electric excitability of axons in the white matter of the brain. This study combined a finite element (FE) model of electroconvulsive therapy (ECT) with a whole-brain tractography analysis as well as the cable theory of neuronal excitation. We have reconstructed a whole-brain tractogram with 500 neural fibres from the diffusion-weighted magnetic resonance scans, and extracted the information on electrical potential from the FE ECT model of the same head. We then calculated the first and second spatial derivatives of the electrical potential, which describes the activating function for homogenous axons and investigated sensitive regions of white matter activation.
AB - Computational human head models have been used in electrophysiological studies, and they have been able to provide useful information that is unable or difficult to acquire from experimental or imaging studies. However, most of these models are purely volume conductor models that overlooked the electric excitability of axons in the white matter of the brain. This study combined a finite element (FE) model of electroconvulsive therapy (ECT) with a whole-brain tractography analysis as well as the cable theory of neuronal excitation. We have reconstructed a whole-brain tractogram with 500 neural fibres from the diffusion-weighted magnetic resonance scans, and extracted the information on electrical potential from the FE ECT model of the same head. We then calculated the first and second spatial derivatives of the electrical potential, which describes the activating function for homogenous axons and investigated sensitive regions of white matter activation.
UR - http://www.scopus.com/inward/record.url?scp=85056668737&partnerID=8YFLogxK
U2 - 10.1109/EMBC.2018.8513489
DO - 10.1109/EMBC.2018.8513489
M3 - Conference contribution
C2 - 30441734
AN - SCOPUS:85056668737
T3 - Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
SP - 6133
EP - 6136
BT - 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2018
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2018
Y2 - 18 July 2018 through 21 July 2018
ER -