A small-molecule antagonist of the Hedgehog signaling pathway

Jongkook Lee; Xu Wu; Marina Pasca Di Magliano; Eric C. Peters; Yan Wang; Jiyong Hong; Metthias Hebrok; Sheng Ding; Charles Y. Cho; Peter G. Schultz

doi:10.1002/cbic.200700403

A small-molecule antagonist of the Hedgehog signaling pathway

Jongkook Lee, Xu Wu, Marina Pasca Di Magliano, Eric C. Peters, Yan Wang, Jiyong Hong, Metthias Hebrok, Sheng Ding, Charles Y. Cho, Peter G. Schultz

Publikation: Beitrag in Fachzeitschrift › Artikel › Begutachtung

68 Zitate (Scopus)

Abstract

(Chemical Equation Presented) Shadow the Hedgehog. JK184 (illustrated in the scheme) was identified as an antagonist of Hedgehog signaling through a cell-based screen of chemical libraries. Results from biochemical and cellular experiments suggest that JK184 functions by inhibiting class IV alcohol dehydrogenase. This molecule should serve as a useful tool for studying Hedgehog signaling.

Originalsprache	Englisch
Seiten (von - bis)	1916-1919
Seitenumfang	4
Fachzeitschrift	ChemBioChem
Jahrgang	8
Ausgabenummer	16
DOIs	https://doi.org/10.1002/cbic.200700403
Publikationsstatus	Veröffentlicht - 5 Nov. 2007
Extern publiziert	Ja

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10.1002/cbic.200700403

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abstract = "(Chemical Equation Presented) Shadow the Hedgehog. JK184 (illustrated in the scheme) was identified as an antagonist of Hedgehog signaling through a cell-based screen of chemical libraries. Results from biochemical and cellular experiments suggest that JK184 functions by inhibiting class IV alcohol dehydrogenase. This molecule should serve as a useful tool for studying Hedgehog signaling.",

keywords = "Alcohol dehydrogenase 7, Hedgehog signaling, Inhibitors, Signal transduction",

author = "Jongkook Lee and Xu Wu and {Di Magliano}, {Marina Pasca} and Peters, {Eric C.} and Yan Wang and Jiyong Hong and Metthias Hebrok and Sheng Ding and Cho, {Charles Y.} and Schultz, {Peter G.}",

year = "2007",

month = nov,

day = "5",

doi = "10.1002/cbic.200700403",

language = "English",

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AU - Wu, Xu

AU - Di Magliano, Marina Pasca

AU - Peters, Eric C.

AU - Wang, Yan

AU - Hong, Jiyong

AU - Hebrok, Metthias

AU - Ding, Sheng

AU - Cho, Charles Y.

AU - Schultz, Peter G.

PY - 2007/11/5

Y1 - 2007/11/5

N2 - (Chemical Equation Presented) Shadow the Hedgehog. JK184 (illustrated in the scheme) was identified as an antagonist of Hedgehog signaling through a cell-based screen of chemical libraries. Results from biochemical and cellular experiments suggest that JK184 functions by inhibiting class IV alcohol dehydrogenase. This molecule should serve as a useful tool for studying Hedgehog signaling.

AB - (Chemical Equation Presented) Shadow the Hedgehog. JK184 (illustrated in the scheme) was identified as an antagonist of Hedgehog signaling through a cell-based screen of chemical libraries. Results from biochemical and cellular experiments suggest that JK184 functions by inhibiting class IV alcohol dehydrogenase. This molecule should serve as a useful tool for studying Hedgehog signaling.

KW - Alcohol dehydrogenase 7

KW - Hedgehog signaling

KW - Inhibitors

KW - Signal transduction

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JO - ChemBioChem

JF - ChemBioChem

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A small-molecule antagonist of the Hedgehog signaling pathway

Abstract

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