TY - JOUR
T1 - A multivariate metabolic imaging marker for behavioral variant frontotemporal dementia
AU - Alzheimer's Disease Neuroimaging Initiative
AU - Nazem, Amir
AU - Tang, Chris C.
AU - Spetsieris, Phoebe
AU - Dresel, Christian
AU - Gordon, Marc L.
AU - Diehl-Schmid, Janine
AU - Grimmer, Timo
AU - Yakushev, Igor
AU - Mattis, Paul J.
AU - Ma, Yilong
AU - Dhawan, Vijay
AU - Eidelberg, David
N1 - Publisher Copyright:
© 2018 The Authors
PY - 2018/1/1
Y1 - 2018/1/1
N2 - Introduction: The heterogeneity of behavioral variant frontotemporal dementia (bvFTD) calls for multivariate imaging biomarkers. Methods: We studied a total of 148 dementia patients from the Feinstein Institute (Center-A: 25 bvFTD and 10 Alzheimer's disease), Technical University of Munich (Center-B: 44 bvFTD and 29 FTD language variants), and Alzheimer's Disease Neuroimaging Initiative (40 Alzheimer's disease subjects). To identify the covariance pattern of bvFTD (behavioral variant frontotemporal dementia–related pattern [bFDRP]), we applied principal component analysis to combined 18F-fluorodeoxyglucose–positron emission tomography scans from bvFTD and healthy subjects. The phenotypic specificity and clinical correlates of bFDRP expression were assessed in independent testing sets. Results: The bFDRP was identified in Center-A data (24.1% of subject × voxel variance; P <.001), reproduced in Center-B data (P <.001), and independently validated using combined testing data (receiver operating characteristics–area under the curve = 0.97; P <.0001). The expression of bFDRP was specifically elevated in bvFTD patients (P <.001) and was significantly higher at more advanced disease stages (P =.035:duration; P <.01:severity). Discussion: The bFDRP can be used as a quantitative imaging marker to gauge the underlying disease process and aid in the differential diagnosis of bvFTD.
AB - Introduction: The heterogeneity of behavioral variant frontotemporal dementia (bvFTD) calls for multivariate imaging biomarkers. Methods: We studied a total of 148 dementia patients from the Feinstein Institute (Center-A: 25 bvFTD and 10 Alzheimer's disease), Technical University of Munich (Center-B: 44 bvFTD and 29 FTD language variants), and Alzheimer's Disease Neuroimaging Initiative (40 Alzheimer's disease subjects). To identify the covariance pattern of bvFTD (behavioral variant frontotemporal dementia–related pattern [bFDRP]), we applied principal component analysis to combined 18F-fluorodeoxyglucose–positron emission tomography scans from bvFTD and healthy subjects. The phenotypic specificity and clinical correlates of bFDRP expression were assessed in independent testing sets. Results: The bFDRP was identified in Center-A data (24.1% of subject × voxel variance; P <.001), reproduced in Center-B data (P <.001), and independently validated using combined testing data (receiver operating characteristics–area under the curve = 0.97; P <.0001). The expression of bFDRP was specifically elevated in bvFTD patients (P <.001) and was significantly higher at more advanced disease stages (P =.035:duration; P <.01:severity). Discussion: The bFDRP can be used as a quantitative imaging marker to gauge the underlying disease process and aid in the differential diagnosis of bvFTD.
KW - Behavioral variant frontotemporal dementia
KW - Differential diagnosis
KW - FDG PET
KW - Quantitative imaging biomarker
KW - Spatial covariance pattern
UR - http://www.scopus.com/inward/record.url?scp=85055661902&partnerID=8YFLogxK
U2 - 10.1016/j.dadm.2018.07.009
DO - 10.1016/j.dadm.2018.07.009
M3 - Article
AN - SCOPUS:85055661902
SN - 2352-8729
VL - 10
SP - 583
EP - 594
JO - Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
JF - Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
ER -
