A general cyclocarbonylation of aryl bromides and triflates with acetylenes: Palladium-catalyzed synthesis of 3-alkylidenefuran-2-ones

Xiao Feng Wu, Basker Sundararaju, Pazhamalai Anbarasan, Helfried Neumann, Pierre H. Dixneuf, Matthias Beller

Publikation: Beitrag in FachzeitschriftArtikelBegutachtung

40 Zitate (Scopus)

Abstract

Making use of CO: An improved efficient synthesis of 5-aryl-3- alkylidenefuran-2-ones has been developed (see scheme). Starting from readily available (hetero)aryl bromides or aryl triflates and alkynes, furanones were produced in good yields through a double carbonylation process. To illustrate the generality of the method more than 25 furanone derivatives were synthesized, including the permethylated kinase inhibitor BE-23372M.

OriginalspracheEnglisch
Seiten (von - bis)8014-8017
Seitenumfang4
FachzeitschriftChemistry - A European Journal
Jahrgang17
Ausgabenummer29
DOIs
PublikationsstatusVeröffentlicht - 11 Juli 2011
Extern publiziertJa

Fingerprint

Untersuchen Sie die Forschungsthemen von „A general cyclocarbonylation of aryl bromides and triflates with acetylenes: Palladium-catalyzed synthesis of 3-alkylidenefuran-2-ones“. Zusammen bilden sie einen einzigartigen Fingerprint.

Dieses zitieren