A challenge for allergologist: Application of allergy diagnostic methods in mast cell disorders

Jan Romantowski, Aleksandra Górska, Marek Niedoszytko, Theo Gulen, Marta Gruchała-Niedoszytko, Bogusław Nedoszytko, Magdalena Lange, Knut Brockow, Michel Arock, Cem Akin, Peter Valent

Publikation: Beitrag in FachzeitschriftÜbersichtsartikelBegutachtung

6 Zitate (Scopus)

Abstract

Primary and secondary mast cell activation syndromes (MCAS) can occur in patients with mastocytosis. During the past few years our knowledge about the pathogenesis and disease-triggering mechanisms in MCAS and mastocytosis have increased substantially. Whereas mastocytosis is characterized by an accumulation of neoplastic (clonal) mast cells (MC) in various organ systems, MCAS is defined by a massive and systemic activation of these cells. Mast cells are crucial effector cells in allergic diseases, thus their elevated number and activation can cause severe anaphylactic reactions and MCAS in patients with mastocytosis. However, these cells may also degranulate spontaneously or degranulate in response to non-allergic triggers leading to clinical symptoms. In mastocytosis patients, such symptoms may lead to the diagnosis of a primary MCAS. The diagnosis of a concomitant allergy in mastocytosis patients is challenging. In these patients, a mixed form (primary and secondary) of MCAS may be diagnosed. These patients may also suffer from life-threatening anaphylactic reactions when exposed to allergens. In these cases, the possibility of severe side effects of in vivo provocations can sometimes also limit diagnostic evaluations. In the current article, we discuss the diagnosis and management of patients suffering from mastocytosis and concomitant MCAS, with special emphasis on novel diagnostic tests and management, including allergen microarrays, recombinant allergen analysis, basophil activation tests, optimal prophylaxis, and specific therapies.

OriginalspracheEnglisch
Aufsatznummer1454
Seiten (von - bis)1-14
Seitenumfang14
FachzeitschriftInternational Journal of Molecular Sciences
Jahrgang22
Ausgabenummer3
DOIs
PublikationsstatusVeröffentlicht - 2 Feb. 2021
Extern publiziertJa

Fingerprint

Untersuchen Sie die Forschungsthemen von „A challenge for allergologist: Application of allergy diagnostic methods in mast cell disorders“. Zusammen bilden sie einen einzigartigen Fingerprint.

Dieses zitieren