A bipolar disorder-associated missense variant alters adenylyl cyclase 2 activity and promotes mania-like behavior

Keyphrases

• Missense Variants 100%
• Bipolar Disorder 100%
• Leucine 100%
• Adenylyl Cyclase 100%
• Manic-like Behavior 100%
• Valine 60%
• Mania 60%
• Monophosphate 40%
• Therapeutic Intervention 20%
• Single nucleotide Polymorphism 20%
• Subcellular Localization 20%
• Disease-associated 20%
• Missense mutation 20%
• MRNA Expression 20%
• Cognitive Impairment 20%
• Signaling Pathway 20%
• Risk Genes 20%
• Underlying Disease 20%
• Second Messenger 20%
• Rodents 20%
• Differentially Expressed Genes 20%
• Cas9 Protein 20%
• Gene Editing 20%
• Single-cell RNA Sequencing (scRNA-seq) 20%
• Biological Processes 20%
• Disease Mechanisms 20%
• Lithium Treatment 20%
• Depressive-like Behavior 20%
• Symptomatology 20%
• Glutamatergic 20%
• Amphetamine 20%
• Hippocampal Neurons 20%
• Chronic Social Defeat Stress 20%
• CA1 Neurons 20%
• Intervention Strategies 20%
• Synaptic Balance 20%
• Bipolar Disorder Risk 20%
• Enzyme Capacity 20%

Neuroscience

• Behavior (Neuroscience) 100%
• Leucine 100%
• Adenylyl Cyclase 100%
• Bipolar Disorder 100%
• Valine 60%
• Cognitive Disorders 20%
• RNA-Seq 20%
• CRISPR 20%
• Second Messenger System 20%
• Missense Mutation 20%
• Social Defeat 20%
• Single-Nucleotide Polymorphism 20%
• Messenger RNA 20%
• Amphetamine 20%

Biochemistry, Genetics and Molecular Biology

• Missense 100%
• Leucine 100%
• Adenylate Cyclase 100%
• Valine 60%
• Subcellular Localization 20%
• Single-Nucleotide Polymorphism 20%
• RNA Sequencing 20%
• Genome Editing 20%
• CRISPR/Cas9 20%
• Glutamatergic 20%
• Enzyme 20%
• Biological Phenomena and Functions Concerning the Entire Organism 20%
• Second Messenger System 20%
• Missense Mutation 20%
• Messenger RNA 20%
• Differentially Expressed Gene 20%