TY - JOUR
T1 - 5-fluorouracil accumulation in green microalgae and its biogenetic transfer into ciliate protozoan
AU - Asad, Ud Daula
AU - Pfister, Gerd
AU - Schramm, Karl Werner
PY - 2012/4
Y1 - 2012/4
N2 - The study has demonstrated that anticancer drug 5-fluorouracil causes acute toxicity and interferes with the growth of green microalgae, Scenedesmus vacuolatus. It accumulates in microalgae biomass with bioaccumulation factor of 1.84 9 104 and further integrates into the DNA and RNA of microalgae. In addition, the labelled microalgae genome is transferred into protozoan Tetrahymena pyriformis on feeding and is retained in the food vacuoles of predator organisms. This biotransfer of labelled 5-fluorouracil via genomic material was evaluated using radioactivity in Tetrahymena cell pellets though radioactivity did not detect anticancer drug in the genome of the predator organism.
AB - The study has demonstrated that anticancer drug 5-fluorouracil causes acute toxicity and interferes with the growth of green microalgae, Scenedesmus vacuolatus. It accumulates in microalgae biomass with bioaccumulation factor of 1.84 9 104 and further integrates into the DNA and RNA of microalgae. In addition, the labelled microalgae genome is transferred into protozoan Tetrahymena pyriformis on feeding and is retained in the food vacuoles of predator organisms. This biotransfer of labelled 5-fluorouracil via genomic material was evaluated using radioactivity in Tetrahymena cell pellets though radioactivity did not detect anticancer drug in the genome of the predator organism.
KW - Bioaccumulation Acute toxicity of 5-fluorouracil
KW - Genetic transfer of 5-FU Microalgae
UR - http://www.scopus.com/inward/record.url?scp=84861161238&partnerID=8YFLogxK
U2 - 10.1007/s00128-012-0536-8
DO - 10.1007/s00128-012-0536-8
M3 - Article
C2 - 22349280
AN - SCOPUS:84861161238
SN - 0007-4861
VL - 88
SP - 548
EP - 554
JO - Bulletin of Environmental Contamination and Toxicology
JF - Bulletin of Environmental Contamination and Toxicology
IS - 4
ER -